Enhanced skin permeation using polyarginine modified nanostructured lipid carriers
نویسندگان
چکیده
منابع مشابه
Nanostructured Lipid Drug Carriers
solid lipid carriers – NLC. Particulate lipid matrices in the form of lipid pellets are known from the textbooks since many years, products are on the market (e. g. Mucosolvan retard, Boehringer-Ingelheim). After these lipid pellets as the first generation, P. Speiser developed so-called “lipid nanopellets for oral administration” in the middle of the eighties [1]. This system was not further d...
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Invasomes are the liposomal vesicles embodying small amounts of ethanol and terpenes or terpene mixtures, which act as potential carriers with increased skin penetration. Invasomes have higher penetration rate through the skin as compared to liposomes and ethosomes. Invasomes provide a number of advantages including improving the drug’s efficacy, enhancing patient compliance and comfort. This a...
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Although sildenafil citrate (SC) is used extensively for erectile dysfunction, oral delivery of SC encounters many obstacles. Furthermore, the physicochemical characteristics of this amphoteric drug are challenging for delivery system formulation and transdermal permeation. This article concerns the assessment of the potential of nanomedicine for improving SC delivery and transdermal permeation...
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Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therape...
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The expression of multiple receptors on intestinal epithelial cells enables an actively targeted carrier to significantly enhance the oral delivery of payloads. Conjugating the receptors' ligands on the surfaces of a particulate-delivery system allows site-specific targeting. Here, we used taurocholic acid (TCA) as a ligand for uptake of nanostructured lipid carriers (NLCs) mediated by a bile-a...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2012
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2012.05.011